Infectious Salmon Anemia  In The United States:  A Synopsis Of Maine’s Experiences With A Devastating Disease     Peter L. Merrill   Micro Technologies, Inc., Richmond, ME     Infectious Salmon Anemia (ISA), an important disease of Atlantic salmon (Salmo salar) caused by the contagious virus ISAV, has caused large-scale economic losses as well as regulatory and political problems internationally since the 1980’s.  As the pathogen and attendant disease have advanced to new environments, most recently Cobscook Bay in Maine, private industry, regulators and conservationists in the US have worked together (and sometimes apart) to deal with the consequences of this syndrome.   A brief overview of the known epidemiological factors involved in the transmission and spread of ISA will be discussed, along with a review of the laboratory tests used for detection of the virus.  A detailed history of the progression of ISA from Canada to the US will be included, and the attempts at dealing with both pathogen and disease from the US and international regulatory perspectives will be examined. Vaccine research and development will also be discussed.  An up-to-date review of the types and successes of ISAV monitoring programs on the private, state and federal levels for both cultured and wild populations will complete the presentation.